Long-term risk of de novo malignancy with tumor necrosis factor alpha (TNF) inhibitor immunosuppression: a multicenter, retrospective cohort study
Patients with TNF-I exposure had higher risk of melanoma, skin SCC and BCC along with lower risk of leukemia, NHL, and PCa. This is consistent with previous melanoma, skin SCC and BCC data and demonstrates novel findings for leukemia, NHL, and PCa. There may need to be differential cancer screening algorithms for patients with different inflammatory conditions and TNF-I exposure.
Authors
- Edward M. Schaeffer (ORCID: https://orcid.org/0000-0003-0699-1899)
- Dylan Isaacson (ORCID: https://orcid.org/0000-0003-1791-504X)
- Steven M. Belknap (ORCID: https://orcid.org/0000-0002-3670-7409)
- Joseph Nicolas (ORCID: https://orcid.org/0000-0002-3795-1120)
- Philip Silberman (ORCID: https://orcid.org/0000-0001-5317-5486)
- William H. Temps (ORCID: https://orcid.org/0000-0001-5561-6396)
- Xinlei Mi (ORCID: https://orcid.org/0000-0002-2966-3217)
- Shilajit Kundu (ORCID: https://orcid.org/0000-0001-5532-1408)
- Conor Driscoll (ORCID: https://orcid.org/0000-0001-7730-6145)
- Jordan Rich (ORCID: https://orcid.org/0000-0002-4434-5321)
- Christopher C. Yang (ORCID: https://orcid.org/0000-0001-5463-6926)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6825-5649)
- S.K.S.R. Kumar (ORCID: https://orcid.org/0009-0003-5679-0435)
Institutions
- Northwestern University (US)
- Cleveland Clinic (US)
- New York University (US)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s12950-025-00445-x
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Northwestern University