Geniposide attenuates obesity-related depression: involvement of decreased neuroinflammation and synaptic engulfment

In summary, this study demonstrates that geniposide alleviates HF diet-induced depressive behaviors, which is associated with improved synaptic health and reduced neuroinflammation in the amygdala. These findings provide a mechanistic basis for the potential repurposing of geniposide in the management of obesity-related affective disorders.