Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma
The arginase BCT-100 profoundly disrupts neuroblastoma growth in vitro and in vivo, an effect enhanced in combination with standard-of-care chemo-immuno-therapy. Our data supports further assessment of arginine-depleting combination therapies as a new treatment strategy for neuroblastoma.
Authors
- Caroline Atkinson
- Alvin Kamili (ORCID: https://orcid.org/0000-0002-4864-1195)
- Murray D. Norris (ORCID: https://orcid.org/0000-0002-0632-4589)
- Erin Mosmann
- Adam Kearns
- Jean B. Bertoldo (ORCID: https://orcid.org/0000-0002-6897-6822)
- Stephanie Alfred (ORCID: https://orcid.org/0009-0006-5504-2904)
- David S. Ziegler (ORCID: https://orcid.org/0000-0001-7451-7916)
- Francis Mussai (ORCID: https://orcid.org/0000-0003-3342-0047)
- Frances K. Kusuma (ORCID: https://orcid.org/0009-0001-5375-0652)
- Kimberley M. Hanssen (ORCID: https://orcid.org/0000-0002-2919-3104)
- Michelle Haber (ORCID: https://orcid.org/0000-0003-2036-8817)
- C. Mak (ORCID: https://orcid.org/0009-0009-3188-7453)
- Laura D. Gamble (ORCID: https://orcid.org/0000-0001-8496-9705)
- Jamie I. Fletcher (ORCID: https://orcid.org/0000-0003-2949-9469)
- Jayne Murray (ORCID: https://orcid.org/0000-0002-1861-6570)
- Paul N. Cheng
- Jennifer Brand
- Ruby Pandher
- Alexis Z Minchaca
Institutions
- The University of Sydney (AU)
- UNSW Sydney (AU)
- Birmingham Children's Hospital (GB)
- International Network for Cancer Treatment and Research (BE)
- Children's Cancer Institute Australia (AU)
- St Vincent's Clinic (AU)
- Sydney Children's Hospital (AU)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s13046-025-03502-8
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Analytical Center for the Government of the Russian Federation
- Cancer Institute NSW
- University of New South Wales
- Medical Research Council
- National Health and Medical Research Council