A mitochondria-targeted sequence-activated fluorescent probe responsive to H<sub>2</sub>O<sub>2</sub> and viscosity for imaging and surgical navigation of hepatocellular carcinoma
A mitochondria-targeted fluorescent probe (HV) sequentially activated by H<sub>2</sub>O<sub>2</sub> and viscosity was constructed. Probe HV exhibits high specificity and excellent biocompatibility. Due to the upregulation of mitochondrial H<sub>2</sub>O<sub>2</sub> and viscosity in cancer cells, HV is capable of illuminating hepatocellular carcinoma. HV surpasses the limitations of single-marker detection of liver cancer and enables powerful imaging-guided hepatic cancer resections, improving the precision of liver diagnosis and treatment.
Authors
- Yuting Sheng (ORCID: https://orcid.org/0009-0000-4510-9075)
- Wen Zhang (ORCID: https://orcid.org/0000-0002-2611-8029)
- Xin Wang (ORCID: https://orcid.org/0009-0000-6446-3272)
- Qiong Wang (ORCID: https://orcid.org/0000-0002-5283-1549)
- Ping Li (ORCID: https://orcid.org/0000-0002-2356-0962)
- Hui Wang (ORCID: https://orcid.org/0000-0002-2346-8621)
- M. Zhang (ORCID: https://orcid.org/0000-0001-8659-5727)
- Bo Tang (ORCID: https://orcid.org/0000-0002-8712-7025)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-9819-2407)
Institutions
- Shandong Normal University (CN)
- Ministry of Education (ME)
- Laoshan Laboratory
- Northwest Normal University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc03664j
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00