Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models
Together, GSOs constitute a tractable and translationally relevant model that faithfully reflects the cellular complexity, genetic landscape, and tumor-specific heterogeneity. This model addresses a critical gap in GS biology and supports its integration into precision oncology.
Authors
- Yeun‐Jun Chung (ORCID: https://orcid.org/0000-0002-6943-5948)
- Youn Soo Lee (ORCID: https://orcid.org/0000-0002-1653-6315)
- Minyoung Park (ORCID: https://orcid.org/0000-0003-4628-147X)
- Hyeon‐Chun Park (ORCID: https://orcid.org/0000-0001-5766-3540)
- Dokyeong Kim (ORCID: https://orcid.org/0000-0002-5154-9613)
- Junseong Park (ORCID: https://orcid.org/0000-0003-0436-8614)
- Stephen Ahn (ORCID: https://orcid.org/0000-0002-6854-1597)
- Minho Lee (ORCID: https://orcid.org/0000-0002-0168-9546)
- Songzi Zhang (ORCID: https://orcid.org/0000-0003-4641-499X)
- Okcho Na
Institutions
- Dongguk University (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s12967-025-06952-y
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Research Foundation
- Catholic University of Korea
- Korea Institute of Science and Technology
- Korea Institute of Science and Technology Information
- National Research Foundation of Korea
- Korea Research Environment Open Network