Mutational signature analysis of chronic lymphocytic leukemia uncovering genomic patterns and prognostic implications
The de novo SBS signatures were identified as being associated with IGHV status, highlighting significant disease heterogeneity that belies the more categorical and limited traditional risk stratification methods. Also, a novel association was made between haloalkane exposure signature and CLL.
Authors
- Michael Yevgeniy Tolstorukov (ORCID: https://orcid.org/0000-0002-9134-8808)
- David Zemmour (ORCID: https://orcid.org/0000-0002-0990-217X)
- Annette S. Kim (ORCID: https://orcid.org/0000-0002-8699-2439)
- Ali AlJabban
- Harrison Kwei Tsai (ORCID: https://orcid.org/0000-0003-1134-9331)
- Katherine Antel (ORCID: https://orcid.org/0000-0002-9000-5504)
- Neal I. Lindeman (ORCID: https://orcid.org/0000-0002-7092-6859)
- Mark Alan Murakami (ORCID: https://orcid.org/0000-0001-9520-2876)
- Elizabeth F. Cohen (ORCID: https://orcid.org/0000-0001-9078-4280)
- Jonathan M. Tsai (ORCID: https://orcid.org/0000-0001-5868-2305)
- David M. Meredith (ORCID: https://orcid.org/0000-0002-7054-8624)
- Lynette M. Sholl (ORCID: https://orcid.org/0000-0002-9532-9735)
- Jennifer Brown (ORCID: https://orcid.org/0000-0002-2126-705X)
- Elizabeth Garcia
- Roberta Santos Azevedo (ORCID: https://orcid.org/0009-0004-2997-6071)
- Allison Arnette
Institutions
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Medical University of South Carolina (US)
- Cornell University (US)
- University of Michigan (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Michigan Medicine (US)
- Dana-Farber Cancer Institute (US)
- Boston Children's Museum (US)
- Weill Cornell Medicine (US)
- Varian Medical Systems (United States) (US)
Publication Details
- Journal
- American Journal of Clinical Pathology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1093/ajcp/aqaf059
- Citations
- 1
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63