Proteomic Profiling of Dentinal Fluid for the Identification of Biomarkers in Pulpal Inflammation: An Exploratory Study
This study identified distinct proteomic differences across pulpitis stages, with unique proteins in severe cases. These findings highlight novel biomarkers for advancing precise, cost-effective, point-of-care diagnostics and therapies, including multiplex platforms or ELISA assays. Proteomic analysis shows promise for understanding disease mechanisms and enabling personalised treatment strategies in endodontics.
Authors
- Valeria Ramı́rez (ORCID: https://orcid.org/0000-0003-2748-4351)
- María José Bendek (ORCID: https://orcid.org/0000-0002-3493-0156)
- Henry Fergus Duncan (ORCID: https://orcid.org/0000-0001-8690-2379)
- Alejandra Chaparro (ORCID: https://orcid.org/0000-0003-0791-7746)
- Claudia Brizuela (ORCID: https://orcid.org/0000-0002-6610-8183)
- Juan J. Segura‐Egea (ORCID: https://orcid.org/0000-0002-0427-9059)
- María Ignacia Valencia
- Camila Alhucema (ORCID: https://orcid.org/0009-0003-3838-1099)
Institutions
- Universidad de Los Andes, Chile (CL)
- Trinity College Dublin (IE)
- Dublin Dental University Hospital (IE)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1111/iej.70017
- Citations
- 3
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- Melissa Institute for Violence Prevention and Treatment
- Agencia Nacional de Investigación y Desarrollo