The transmission blocking activity of artemisinin-combination, non-artemisinin, and 8-aminoquinoline antimalarial therapies: A pooled analysis of individual participant data
We found marked differences among ACTs and single low-dose 8-aminoquinoline drugs in their ability and speed to block transmission. The findings from this analysis can support treatment policy decisions for malaria elimination and be integrated into mathematical models to improve the accuracy of predictions regarding community transmission and the spread of drug resistance under varying treatment guidelines.
Authors
- Alassane Dicko (ORCID: https://orcid.org/0000-0003-2153-8427)
- Seydina O Maguiraga
- Youssouf Sinaba
- Jordache Ramjith (ORCID: https://orcid.org/0000-0003-4431-7395)
- Michelle E. Roh (ORCID: https://orcid.org/0000-0002-6268-0801)
- Halimatou Diawara (ORCID: https://orcid.org/0000-0001-5361-1532)
- Teun Bousema (ORCID: https://orcid.org/0000-0003-2666-094X)
- CHRIS J. DRAKELEY (ORCID: https://orcid.org/0000-0003-4863-075X)
- Joelle Brown (ORCID: https://orcid.org/0000-0002-6044-2906)
- Roly Gosling (ORCID: https://orcid.org/0000-0001-6291-0024)
- Leen N. Vanheer (ORCID: https://orcid.org/0000-0002-7680-385X)
- Siaka Samaké
- Ahamadou Youssouf
- Makonon Diallo
- Kjerstin Lanke (ORCID: https://orcid.org/0000-0001-8970-8432)
- Merel Smit (ORCID: https://orcid.org/0000-0003-4629-2654)
- Sidi M. Niambele (ORCID: https://orcid.org/0000-0001-9442-1153)
- William J. Stone (ORCID: https://orcid.org/0000-0002-6647-0166)
- Almahamoudou Mahamar (ORCID: https://orcid.org/0000-0003-3367-3351)
- Sekouba Keita
- Sékou F. Traorè (ORCID: https://orcid.org/0000-0002-8165-0923)
- Koualy Sanogo
Institutions
- Radboud University Nijmegen (NL)
- University of California, San Francisco (US)
- Radboud University Medical Center (NL)
- London School of Hygiene & Tropical Medicine (GB)
- Global Brain Health Institute (US)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1371/journal.pmed.1004683
- Citations
- 2
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Bill and Melinda Gates Foundation
- Wellcome Trust
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council