The genetic architecture of cervical length is shared with spontaneous preterm birth risk
These results suggest that a large proportion of genetic loci for preterm birth exert their influence through the process of cervical remodeling. Polygenic profiling of maternal genetic liability to cervical shortening could aid in the development of clinical risk assessment tools to identify high-risk women who may benefit from more frequent cervical length screening and earlier interventions to prevent preterm delivery.
Authors
- Timothy P. York (ORCID: https://orcid.org/0000-0003-4068-4286)
- Nardhy Gomez‐Lopez (ORCID: https://orcid.org/0000-0002-3406-5262)
- Stanley M. Berry
- Tinnakorn Chaiworapongsa (ORCID: https://orcid.org/0000-0001-5108-3369)
- Hope M. Wolf (ORCID: https://orcid.org/0000-0003-0888-5272)
- Adi Laurentiu Tarca (ORCID: https://orcid.org/0000-0003-1712-7588)
- Shawn J. Latendresse (ORCID: https://orcid.org/0000-0003-3109-5033)
- Roberto J. Romero (ORCID: https://orcid.org/0000-0002-4448-5121)
- Bradley T. Webb (ORCID: https://orcid.org/0000-0002-0576-5366)
- Jerome F. Strauss (ORCID: https://orcid.org/0000-0001-6199-0480)
- Sonia S. Hassan (ORCID: https://orcid.org/0000-0001-7584-6252)
- P. Chaemsaithong (ORCID: https://orcid.org/0000-0002-4368-0494)
Institutions
- Baylor University (US)
- RTI International (US)
- Virginia Commonwealth University (US)
- Wayne State University (US)
- Washington University in St. Louis (US)
- Mahidol University (TH)
- University of Michigan (US)
- Ramathibodi Hospital (TH)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University of Pennsylvania (US)
- Michigan State University (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1038/s43856-025-01078-0
- Citations
- 2
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- U.S. Department of Health and Human Services
- March of Dimes Foundation
- Wayne State University
- University of Pennsylvania
- Baylor University
- Michigan State University
- RTI International
- Virginia Commonwealth University
- Australian Government
- National Institutes of Health
- College of Engineering, Michigan State University
- Perelman School of Medicine, University of Pennsylvania
- School of Medicine, Virginia Commonwealth University
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NHLBI Division of Intramural Research