Intravenous tenecteplase is associated with a higher incidence of thrombus movement before endovascular treatment for acute ischemic stroke: a secondary analysis of the AcT randomized controlled trial
IV tenecteplase is associated with higher thrombus migration rates before EVT compared with alteplase, which is linked to better functional outcomes. However, the type of thrombolytic agent did not affect final reperfusion and functional outcomes.
Authors
- Faysal Benali
- Houman Khosravani (ORCID: https://orcid.org/0000-0002-4059-9420)
- Anas Alrohimi (ORCID: https://orcid.org/0000-0001-7601-6920)
- Aleksandra Pikula (ORCID: https://orcid.org/0000-0001-7077-0148)
- Jai Shankar (ORCID: https://orcid.org/0000-0002-3707-9723)
- MacKenzie Horn (ORCID: https://orcid.org/0000-0002-1472-3977)
- Aleksander Tkach (ORCID: https://orcid.org/0009-0009-4063-4431)
- Gordon Gubitz
- Andrew M. Demchuk (ORCID: https://orcid.org/0000-0002-4930-7789)
- Brian H Buck (ORCID: https://orcid.org/0000-0002-7984-6062)
- Mohammed Almekhlafi (ORCID: https://orcid.org/0000-0001-9550-8197)
- Dar Dowlatshahi (ORCID: https://orcid.org/0000-0003-1379-3612)
- Heather Williams
- Mahesh Kate (ORCID: https://orcid.org/0000-0003-4794-2882)
- Nishita Singh (ORCID: https://orcid.org/0000-0003-3647-0904)
- Fouzi Bala (ORCID: https://orcid.org/0000-0001-6748-2081)
- Thalia Shoshana Field (ORCID: https://orcid.org/0000-0002-1176-0633)
- Ayoola Ademola (ORCID: https://orcid.org/0000-0002-8412-6246)
- Alexandre Yves Poppe (ORCID: https://orcid.org/0000-0002-1419-2635)
- Luciana Catanese (ORCID: https://orcid.org/0000-0002-8696-5211)
- Bijoy K. Menon (ORCID: https://orcid.org/0000-0002-3466-496X)
- Tolulope T. Sajobi (ORCID: https://orcid.org/0000-0002-5696-5552)
- Ramana Appireddy (ORCID: https://orcid.org/0000-0003-1831-5804)
- F. Moreau (ORCID: https://orcid.org/0000-0001-6096-2824)
- Noman Ishaque (ORCID: https://orcid.org/0000-0002-6032-5005)
- Ibrahim Alhabli (ORCID: https://orcid.org/0000-0002-6293-6934)
- Atif Zafar (ORCID: https://orcid.org/0000-0002-2738-5225)
- Richard H. Swartz (ORCID: https://orcid.org/0000-0001-6571-5531)
Institutions
- Université de Tours (FR)
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Université de Sherbrooke (CA)
- University of British Columbia (CA)
- University of Ottawa (CA)
- University of Alberta (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Toronto Western Hospital (CA)
- Queen Elizabeth II Health Sciences Centre (CA)
- Hillsborough Hospital (CA)
- Kelowna General Hospital (CA)
- McMaster University Medical Centre (CA)
- Maastricht University (NL)
- Centre Hospitalier Universitaire de Tours (FR)
- Centre Hospitalier de l’Université de Montréal (CA)
- University of Manitoba (CA)
- Hamilton Health Sciences (CA)
Publication Details
- Journal
- Journal of NeuroInterventional Surgery
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1136/jnis-2025-023336
- Citations
- 1
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.35