Palladium-Catalyzed Cascade Transformations of 1,4-Diyn-3-yl Carbonates to Construct Cyclobutane-Embedded Frameworks
A palladium-catalyzed autotandem reaction between 1,4-diyn-3-yl carbonates and <i>ortho</i>-functionalized activated alkenes is presented, proceeding through a sequential allenylation, vinylogous addition, and intramolecular propargylation process. A broad array of fused and spirocyclic architectures that include a cyclobutane motif are straightforwardly constructed in moderate to good yields with high regio- and diastereoselectivity.
Authors
- Wei Du (ORCID: https://orcid.org/0000-0003-4162-1471)
- Ze-Liang He
- Hao Wang (ORCID: https://orcid.org/0000-0001-7594-7387)
- Zhichao Chen (ORCID: https://orcid.org/0000-0001-9666-4183)
- Ying‐Chun Chen (ORCID: https://orcid.org/0000-0003-1902-0979)
- Li Li (ORCID: https://orcid.org/0000-0001-5324-2271)
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1021/acs.orglett.5c02986
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sichuan Province Science and Technology Support Program