PEDF-Expressing mesenchymal stem cells restore ovarian function via Tim-3-Mediated immune modulation in primary ovarian failure
This study demonstrates that PEDF-engineered BMSCs rejuvenate ovarian function by dual mechanisms: enhancing Treg-mediated immune tolerance via the Tim-3/Gal-9 axis and promoting follicular survival. These findings position BMSCs-PEDF as a transformative, mechanism-driven therapy for POF, with broad implications for autoimmune-related infertility.
Authors
- Seyida Yimamuyushan
- Jinling Yi
- Aikeremujiang Muheremu (ORCID: https://orcid.org/0000-0002-1690-9644)
- Song Shi
Institutions
- Xinjiang Medical University (CN)
- Fifth Affiliated Hospital of Xinjiang Medical University (CN)
- Sixth Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s13048-025-01778-0
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Natural Science Foundation of Xinjiang