SLC6A3 gene methylation may be associated with alcohol use disorder, but personality and life stress may not influence methylation

The methylation of the SLC6A3 gene may be marginally associated with AUD; however, the rs27072 genotype, personality, and life stress may not be directly linked to epigenetic modifications. Cross-sectional epigenetic studies may not establish causality; future studies with larger, more diverse cohorts and longitudinal designs are warranted to elucidate the complex interplay in AUD pathophysiology.

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Publication Details

Journal
CNS Spectrums
Published
2025-01-01
DOI
https://doi.org/10.1017/s1092852925100473
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
0.00
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SLC6A3 gene methylation may be associated with alcohol use disorder, but personality and life stress may not influence methylation

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SLC6A3 gene methylation may be associated with alcohol use disorder, but personality and life stress may not influence methylation

Chih-Yun Huang, Chun‐Yen Chen, Yi‐Wei Yeh, Shin-Min Lee, Shin-Chang Kuo, Te-En Chyou, San‐Yuan Huang, Chun‐Long Lin
article en

Abstract

The methylation of the SLC6A3 gene may be marginally associated with AUD; however, the rs27072 genotype, personality, and life stress may not be directly linked to epigenetic modifications. Cross-sectional epigenetic studies may not establish causality; future studies with larger, more diverse cohorts and longitudinal designs are warranted to elucidate the complex interplay in AUD pathophysiology.

CNS SpectrumsVol. 30(1)
Ministry of Health and Welfare (KR), Tri-Service General Hospital (TW), Taoyuan Armed Forces General Hospital (TW), Ministry of Health and Welfare (TW), Bali Psychiatric Center (TW), National Defense Medical College (JP), Ministry of Health and Family Welfare (BD), National Defense Medical Center (TW)
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Epigenetics and DNA Methylation
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