Examining whether inflammation mediates effects of genetic risk and trauma on psychopathology
We found little evidence that interleukin-6 or C-reactive protein mediated the pathway between genetic liability for psychiatric phenotypes or trauma and subsequent psychopathology. Longitudinal investigation of other inflammatory and non-inflammatory pathways is required to identify modifiable targets and inform novel treatment strategies for individuals at genetic or trauma-related risk of psychiatric illness.
Authors
- Stanley Zammit (ORCID: https://orcid.org/0000-0002-2647-9211)
- Jérémy Hall (ORCID: https://orcid.org/0000-0002-0403-3278)
- Golam Mohammed Khandaker (ORCID: https://orcid.org/0000-0002-4935-9220)
- Philippa Lilford (ORCID: https://orcid.org/0000-0002-3116-1400)
- Gemma Hammerton (ORCID: https://orcid.org/0000-0002-7781-3857)
- Hannah Jones (ORCID: https://orcid.org/0000-0002-5883-9605)
Institutions
- Avon and Wiltshire Mental Health Partnership NHS Trust (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- National Institute for Health and Care Research (GB)
- University of Bristol (GB)
- Cardiff University (GB)
- Cardiff Metropolitan University (GB)
Publication Details
- Journal
- BJPsych Open
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1192/bjo.2025.10054
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- University Hospitals Bristol NHS Foundation Trust
- International Seafood Sustainability Foundation
- National Institute for Health and Care Research
- Department of Health and Social Care
- Cardiff University
- University of Bristol
- Medical Research Council