[Role and mechanism of microRNA-145-5p in hypoxia-induced pyroptosis of human alveolar epithelial cells].
In human alveolar epithelial cells, miR-145-5p can down-regulate Nrf2 by targeting Sirt5, thereby increasing ROS expression and inducing pyrodeath.
Authors
- Zhenting Liang (ORCID: https://orcid.org/0009-0007-0335-4831)
- Pu Mao (ORCID: https://orcid.org/0000-0002-5017-1073)
- Yongxin Zheng (ORCID: https://orcid.org/0000-0002-2844-7985)
- Rong Yuan (ORCID: https://orcid.org/0000-0001-9996-7331)
- Yongbo Huang (ORCID: https://orcid.org/0000-0001-6798-0451)
- Yonghao Xu (ORCID: https://orcid.org/0000-0002-6857-0152)
- Jinglan Shan
- Jun Guo (ORCID: https://orcid.org/0000-0002-3685-939X)
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3760/cma.j.cn121430-20240217-00134
- Primary Topic
- Inflammasome and immune disorders
- Type
- article