The mechanism of Ningxin-Tongyu-Zishen formula regulating probdnf/mbdnf balance through PAI-1/tPA signaling pathway in the treatment of premature ovarian insufficiency
Our findings demonstrate that NTZF attenuates PAI-1 expression, diminishes tPA-PAI-1 complex formation, and potentiates tPA-dependent proteolysis of proBDNF into mBDNF, thereby restoring their balance. This restores proBDNF/mBDNF balance, suppresses OGCs apoptosis, and ultimately ameliorates POI.
Authors
- Yizhou Zhang (ORCID: https://orcid.org/0000-0002-9316-6581)
- Lifang Xie (ORCID: https://orcid.org/0000-0002-2682-4943)
- Shuaiqi An (ORCID: https://orcid.org/0009-0008-6418-2567)
- Chaofan Zhu
- Zaiyang Zhang
- Jiawen Ma
- Keying Wang (ORCID: https://orcid.org/0009-0001-1994-1535)
Institutions
- Zhejiang Chinese Medical University (CN)
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s13048-025-01769-1
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Zhejiang Chinese Medical University