ALKBH5 modulates COL5A1 mRNA stability via m6A demethylation to promote tobacco carcinogen NNK-induced lung cancer occurrence and progression
ALKBH5 drives NNK-induced lung cancer via m6A demethylation of COL5A1, promoting tumor progression. Targeting the ALKBH5-COL5A1 axis may offer therapeutic strategies against tobacco-related cancers.
Authors
- Li Tu (ORCID: https://orcid.org/0000-0002-4811-6569)
- Yiheng Du (ORCID: https://orcid.org/0000-0002-5092-6448)
- Qiaoyuan Yang (ORCID: https://orcid.org/0000-0001-9123-1127)
- Enwu Xu (ORCID: https://orcid.org/0000-0003-2596-2030)
- Huanliang Huang
- Dexiong Chen
- Xin Li (ORCID: https://orcid.org/0000-0002-2428-5704)
- Jiaxin Zhou (ORCID: https://orcid.org/0000-0002-6686-611X)
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- General Hospital of Guangzhou Military Command (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.010
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Guangdong Province
- Scientific Research Fund of Liaoning Provincial Education Department