Neutralizing GM-CSF autoantibodies impair neutrophil antifungal effector function in a patient with aspergillosis
Invasive aspergillosis may occur in patients with neutralizing GM-CSF Aabs, even in the absence of PAP or other opportunistic infections. GM-CSF Aabs impair GM-CSF-mediated neutrophil activation and Aspergillus-induced ROS production, which may contribute to the invasive fungal infection susceptibility. GM-CSF Aabs should be tested in putatively immunocompetent individuals who develop invasive mold disease.
Authors
- Douglas B. Kuhns (ORCID: https://orcid.org/0000-0002-9971-0760)
- Michail S. Lionakis (ORCID: https://orcid.org/0000-0003-4994-9500)
- Joseph Pechacek
- Jigar V. Desai (ORCID: https://orcid.org/0000-0002-8823-0796)
- Steven M. Holland (ORCID: https://orcid.org/0000-0003-3207-5464)
- Lindsey B. Rosen (ORCID: https://orcid.org/0000-0001-5894-3878)
- Andrew Wishart (ORCID: https://orcid.org/0000-0002-2531-6349)
- Seyedmojtaba Seyedmousavi (ORCID: https://orcid.org/0000-0002-6194-7447)
- Tobias M. Hohl (ORCID: https://orcid.org/0000-0002-9097-5412)
- Marissa A. Zarakas
- Stefania Pittaluga
- Taura Webb
Institutions
- National Institutes of Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- Frederick National Laboratory for Cancer Research (US)
- National Institute of Allergy and Infectious Diseases (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- National Institutes of Health Clinical Center (US)
- Organogenesis (United States) (US)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.jinf.2025.106588
- Citations
- 4
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- U.S. Department of Health and Human Services
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases