Pharmacokinetic Assessment of Drug Efflux from Erythrocytes Loaded with Corticosteroid Esters
The proposed PK methodology well characterized the input properties of RBC-loaded controlled-release formulations of corticosteroids in animal and humans in context of the flip-flop kinetics of the released drug. The model may be relevant to other types of RBC-loaded therapeutic agents.
Authors
- William J. Jusko (ORCID: https://orcid.org/0000-0003-4027-0550)
- Ruihong Yu (ORCID: https://orcid.org/0000-0002-9688-4896)
Institutions
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1007/s11095-025-03913-4
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences