Effect of Enhanced Versus Usual Mobilization Activities in Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
This review demonstrates that enhanced mobilization likely reduces the incidence of ICU-acquired weakness and may reduce duration of delirium, while supporting prior findings that there is little to no difference in risk of adverse events. Early mobilization may be the most promising avenue for optimizing mobilization activities and raise the question of whether the key to improving outcomes lies in early exposure to these activities rather than increased intensity.
Authors
- Anna Krupp (ORCID: https://orcid.org/0000-0002-0815-9441)
- Michele C. Balas (ORCID: https://orcid.org/0000-0003-4009-864X)
- Amy Kim (ORCID: https://orcid.org/0000-0001-8877-3777)
- Janet Aldrich (ORCID: https://orcid.org/0009-0005-8117-5295)
- Etri Kocaqi
- J. Chen
- Saifur Rahman Chowdhury (ORCID: https://orcid.org/0000-0003-4361-0792)
- Karin Dearness (ORCID: https://orcid.org/0000-0002-6854-0156)
- Sonya Kim (ORCID: https://orcid.org/0000-0001-7454-2476)
- Patrick N. A. Harris (ORCID: https://orcid.org/0000-0002-2895-0345)
- Dipayan Chaudhuri (ORCID: https://orcid.org/0000-0002-8305-1481)
- Michelle E. Kho (ORCID: https://orcid.org/0000-0003-3170-031X)
- Bethany Young (ORCID: https://orcid.org/0000-0003-2022-5779)
- Joanna L. Stollings (ORCID: https://orcid.org/0000-0001-6792-1646)
- Kallirroi Laiya Carayannopoulos (ORCID: https://orcid.org/0000-0001-9041-9216)
- Molly McNett (ORCID: https://orcid.org/0000-0002-1059-2535)
- Kimberley Lewis (ORCID: https://orcid.org/0000-0001-6610-3369)
- Jude Manalo
Institutions
- University of Iowa (US)
- Nebraska Medical Center (US)
- Allen Institute for Brain Science (US)
- University of California, San Francisco (US)
- Hospital of the University of Pennsylvania (US)
- University of Iowa Health Care (US)
- Impact (CA)
- The Ohio State University (US)
- University of Nebraska Medical Center (US)
- St. Joseph’s Healthcare Hamilton (CA)
- Vanderbilt University Medical Center (US)
- McMaster University (CA)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1097/ccm.0000000000006840
- Citations
- 4
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.18