Prolonged dengue viremia with predominantly ocular manifestations in a lung transplant recipient

This was an unusual presentation of dengue involving an immune-privileged site in an immunocompromised host. The competing priorities of facilitating immune-mediated clearance of viraemia versus controlling ocular inflammation posed a significant therapeutic challenge. A greater understanding of the pathophysiology of dengue eye disease, including virus-mediated and immune-mediated factors, as well as the development of therapeutic options, is critically required.

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Publication Details

Journal
BMC Infectious Diseases
Published
2025-08-14
DOI
https://doi.org/10.1186/s12879-025-11456-7
Primary Topic
Mosquito-borne diseases and control
Type
article
Field-Weighted Citation Impact
0.00
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article

Prolonged dengue viremia with predominantly ocular manifestations in a lung transplant recipient

Ian Marr, Leong Shuen Loo, Nadine Ali, Michael Zhang et al.
BMC Infectious Diseases
Mosquito-borne diseases and control
article

Prolonged dengue viremia with predominantly ocular manifestations in a lung transplant recipient

Ian Marr, Leong Shuen Loo, Nadine Ali, Michael Zhang, Jane M. Wells
article en

Abstract

This was an unusual presentation of dengue involving an immune-privileged site in an immunocompromised host. The competing priorities of facilitating immune-mediated clearance of viraemia versus controlling ocular inflammation posed a significant therapeutic challenge. A greater understanding of the pathophysiology of dengue eye disease, including virus-mediated and immune-mediated factors, as well as the development of therapeutic options, is critically required.

BMC Infectious DiseasesVol. 25(1)
Canberra Hospital (AU), Menzies School of Health Research (AU)
Openalex Percentile: Top 72%
Mosquito-borne diseases and control
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