Airway basal stem cell-derived extracellular vesicles drive ECM remodeling and suppress fibroblasts activation via the miR-30a-5p/FAP axis in benign tracheal stenosis
These findings suggest that BSC-EVs represent a promising therapeutic strategy for BTS by inhibiting fibroblast activation and promoting ECM remodeling via the miR-30a-5p/FAP axis, offering a novel advancement beyond current treatment approaches.
Authors
- Zhuquan Su (ORCID: https://orcid.org/0000-0002-5583-0349)
- Ruiyue Zhao (ORCID: https://orcid.org/0000-0001-5242-0785)
- Liqun Luo (ORCID: https://orcid.org/0000-0001-5467-9264)
- Huanjie Chen
- Junfeng Huang (ORCID: https://orcid.org/0000-0002-1672-3751)
- Difei Chen (ORCID: https://orcid.org/0000-0002-9587-6501)
- Zhucheng Chen (ORCID: https://orcid.org/0000-0002-8684-0339)
- Shiyue Li (ORCID: https://orcid.org/0000-0001-9622-5623)
- Yuxia Deng
- Jinsheng Lin
- Yingying Gu (ORCID: https://orcid.org/0000-0001-9004-1823)
- Xinlu Wang (ORCID: https://orcid.org/0000-0003-1997-5687)
- Huijie Yang
- Yongwen He (ORCID: https://orcid.org/0000-0002-7533-7244)
- Minting Wu (ORCID: https://orcid.org/0000-0001-5201-5528)
- Ning Ma
Institutions
- Guangzhou Experimental Station (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.014
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- State Key Laboratory of Respiratory Disease