A Comprehensive Review of Genetic Mutations Occurring in the Development and Progression of Gastric Cancer
Our analysis revealed various genetic and molecular alterations in GC, including the overexpression of receptors and cancer-causing genes and the inactivation of tumor-suppressing genes. APC, ATM, BRCA1, BRCA2, CDH1, CDH2, MLH1, MSH2, MSH6, SMAD4, TP53, PIK3CA, and RHOA were linked to the onset and progression of GC, with CDH1 mutations emerging as the most prevalent. Identifying the genetic alterations underlying the onset and development of GC is essential, as it can enable prompt diagnosis and help establish effective preventive measures for this condition.
Authors
- Qianqian Xu (ORCID: https://orcid.org/0000-0002-8056-2518)
- Aling Shen (ORCID: https://orcid.org/0000-0002-5081-3523)
- Mengting Chen
- Kunyu Han
- Zhuo Chen (ORCID: https://orcid.org/0000-0002-4001-0452)
- Yalan Li (ORCID: https://orcid.org/0000-0002-1925-7928)
- Zhuqing Zhang (ORCID: https://orcid.org/0000-0002-2731-0821)
- Xiaoyan Fu (ORCID: https://orcid.org/0000-0002-2939-7748)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Digestive Diseases
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1159/000547374
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00