Immunoglobulin G Receptors (FcγR), in Addition to Target-Antigen and Neonatal Fc Receptor (FcRn), Influence Rituximab Pharmacokinetics

The pharmacokinetics of rituximab are mediated both by Fab (target) interactions and by FcγR and FcRn interactions.

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Publication Details

Journal
Clinical Pharmacokinetics
Published
2025-08-14
DOI
https://doi.org/10.1007/s40262-025-01549-6
Primary Topic
Monoclonal and Polyclonal Antibodies Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Immunoglobulin G Receptors (FcγR), in Addition to Target-Antigen and Neonatal Fc Receptor (FcRn), Influence Rituximab Pharmacokinetics

Céline Desvignes, Denis Mulleman, Théodora Bejan‐Angoulvant, Guillaume Cartron et al.
Clinical Pharmacokinetics
Monoclonal and Polyclonal Antibodies Research
article

Immunoglobulin G Receptors (FcγR), in Addition to Target-Antigen and Neonatal Fc Receptor (FcRn), Influence Rituximab Pharmacokinetics

Céline Desvignes, Denis Mulleman, Théodora Bejan‐Angoulvant, Guillaume Cartron, David Ternant, Gilles Paintaud, Amina Bensalem, Olivier Le Tilly, Valérie Gouilleux‐Gruart
article en

Abstract

The pharmacokinetics of rituximab are mediated both by Fab (target) interactions and by FcγR and FcRn interactions.

Clinical PharmacokineticsVol. 64(11)
Université de Tours (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Université de Montpellier (FR), Centre Hospitalier Universitaire de Montpellier (FR), Centre Hospitalier Universitaire de Tours (FR), Centre de Biophysique Moléculaire (FR), Thion Medical (France) (FR), Laboratoire d'Informatique Fondamentale et Appliquée de Tours (FR), Services déconcentrés d'appui à la recherche Occitanie-Montpellier (FR)
Good health and well-being
Openalex Percentile: Top 71%
Monoclonal and Polyclonal Antibodies Research
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Immunoglobulin G Receptors (FcγR), in Addition to Target-Antigen and Neonatal Fc Receptor (FcRn), Influence Rituximab Pharmacokinetics — Céline Desvignes, Denis Mulleman, et al. · Clinical Pharmacokinetics (2025) | TGRS Research Map | TGRS