Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia
Accelerated biological age is associated with lower cognition and a higher risk of dementia in midlife and more prominently in late life.
Authors
- Ruth F. Dubin (ORCID: https://orcid.org/0000-0002-0498-1980)
- Alexis C. Wood (ORCID: https://orcid.org/0000-0001-7616-2119)
- Shuo Wang (ORCID: https://orcid.org/0000-0003-2927-6548)
- James S. Pankow (ORCID: https://orcid.org/0000-0001-7076-483X)
- Jerome I. Rotter (ORCID: https://orcid.org/0000-0001-7191-1723)
- Ramon Casanova (ORCID: https://orcid.org/0000-0002-6934-5942)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Rajat Deo (ORCID: https://orcid.org/0000-0002-8250-2607)
- Weihong Tang (ORCID: https://orcid.org/0000-0003-1200-0270)
- Timothy M. Hughes (ORCID: https://orcid.org/0000-0002-2919-7199)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Peter Ganz (ORCID: https://orcid.org/0000-0002-0437-8882)
- Saeun Park (ORCID: https://orcid.org/0000-0003-0482-4667)
- Anna E. Prizment (ORCID: https://orcid.org/0000-0001-5924-6871)
- Behnam Sabayan (ORCID: https://orcid.org/0000-0002-1176-9152)
- Pamela L. Lutsey (ORCID: https://orcid.org/0000-0002-1572-1340)
- Sanaz Sedaghat (ORCID: https://orcid.org/0000-0002-8296-1811)
- Rob F. Walker (ORCID: https://orcid.org/0000-0002-1151-3675)
- Jialing Liu (ORCID: https://orcid.org/0000-0002-8242-2455)
- Weihua Guan
Institutions
- San Francisco General Hospital (US)
- University of Minnesota (US)
- Agricultural Research Service (US)
- University of California, San Francisco (US)
- UCLA Medical Center (US)
- University of Minnesota Medical Center (US)
- National Institute on Aging (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
- Minnesota Department of Health (US)
- Hennepin Healthcare Research Institute (US)
- Wake Forest University (US)
- New York University (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1038/s43856-025-01096-y
- Citations
- 2
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- Gillings School of Public Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute on Deafness and Other Communication Disorders
- National Institute of Neurological Disorders and Stroke