A novel broad host range phage phiA85 displays a synergistic effect with antibiotics targeting carbapenem-resistant <i>Klebsiella pneumoniae</i>

The widespread prevalence of MDR bacteria has become a critical public health threat with limited therapeutic options. This study identifies a novel broad host range phage phiA85, capable of lysing strains across different KL types of CRKP. This characteristic addresses the limitation of narrow host range of capsular-specific phages, thereby significantly expanding their therapeutic potential against multidrug-resistant bacterial infections. Phage phiA85-antibiotic combinations achieve PAS, enhancing lytic activity and biofilm inhibition <i>in vitro</i> and alleviating mouse pneumonia. These findings highlight that phage phiA85-antibiotic combinations are a promising strategy to combat MDR-CRKP infections. Our work provides critical insights into optimizing phage therapy for clinical use against priority pathogens.

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Publication Details

Journal
Microbiology Spectrum
Published
2025-08-15
DOI
https://doi.org/10.1128/spectrum.02019-25
Citations
1
Primary Topic
Bacteriophages and microbial interactions
Type
article
Field-Weighted Citation Impact
1.72

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article

A novel broad host range phage phiA85 displays a synergistic effect with antibiotics targeting carbapenem-resistant Klebsiella pneumoniae

Ziying Xu, Guanhua Xue, Bing Du, Yuehua Ke et al.
1 citations
Microbiology Spectrum
Bacteriophages and microbial interactions
1.72
article

A novel broad host range phage phiA85 displays a synergistic effect with antibiotics targeting carbapenem-resistant Klebsiella pneumoniae

Ziying Xu, Guanhua Xue, Bing Du, Yuehua Ke, Chao Yan, Xiaohu Cui, Zhoufei Li, Zihui Yu, Yang Yang, Lin Gan, Yu‐Chen Chen, Hanqing Zhao, Jing Yuan, Junxia Feng, Zheng Fan, Tongtong Fu, Jinghua Cui, Yanling Feng
article en
1 citations

Abstract

The widespread prevalence of MDR bacteria has become a critical public health threat with limited therapeutic options. This study identifies a novel broad host range phage phiA85, capable of lysing strains across different KL types of CRKP. This characteristic addresses the limitation of narrow host range of capsular-specific phages, thereby significantly expanding their therapeutic potential against multidrug-resistant bacterial infections. Phage phiA85-antibiotic combinations achieve PAS, enhancing lytic activity and biofilm inhibition <i>in vitro</i> and alleviating mouse pneumonia. These findings highlight that phage phiA85-antibiotic combinations are a promising strategy to combat MDR-CRKP infections. Our work provides critical insights into optimizing phage therapy for clinical use against priority pathogens.

Microbiology SpectrumVol. 13(10)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN), Capital Institute of Pediatrics (CN)
National Natural Science Foundation of China
Good health and well-being
Openalex Percentile: Top 15%
Bacteriophages and microbial interactions
1.72
DOIOpen Access PDFOpenAlex
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