Microbiome-metabolome generated bile acids gatekeep infliximab efficacy in Crohn’s disease by licensing M1 suppression and Treg dominance
These findings establish gut microbiome composition, particularly Bifidobacterium abundance, as a critical determinant of anti-TNF response in CD, mediated through bile acid-dependent regulation of Treg/M1 macrophage homeostasis. While multi-omics integration did not enhance predictive performance, microbiome-based machine learning models offer clinically actionable biomarkers for treatment stratification, providing a roadmap for precision therapy to overcome biological resistance in inflammatory bowel disease.
Authors
- Huiying Liang (ORCID: https://orcid.org/0000-0003-0407-0383)
- Liping Liang (ORCID: https://orcid.org/0000-0001-8113-1931)
- Wanyan Zhou
- Le Liu (ORCID: https://orcid.org/0000-0002-9270-9951)
- Genghui Mai
- Mingming Wang (ORCID: https://orcid.org/0009-0005-9972-5056)
- Ye Chen (ORCID: https://orcid.org/0000-0002-7964-7899)
- Chenghai Yang
Institutions
- Nanfang Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.017
- Citations
- 5
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 9.09
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Shenzhen Science and Technology Innovation Program