LC–MS‐Based Serum Pharmacochemistry Combined With Network Pharmacology and Pharmacodynamics to Evaluate the Role of Macromolecular Components in TCMs' Decoction: A Case Study on Qi‐Huo‐Yi‐Fei Decoction for COPD Therapy
QH-M was not only effective independently on COPD but also showed integrative effects with the coexisting QH-S in improving their absorption, thus strengthening the component-target interactions, and consequently contributing to the COPD therapeutic effects of QH. Therefore, it was confirmed that QH-M was essential for QH's COPD therapy and should not be removed during the modern preparation development.
Authors
- Peng Yang (ORCID: https://orcid.org/0009-0009-9238-9466)
- Cheng‐Ying Wu (ORCID: https://orcid.org/0000-0001-5999-0780)
- Jin‐Di Xu
- Fang Long (ORCID: https://orcid.org/0000-0002-4744-7155)
- Qingling Xiao
- Song‐Lin Li (ORCID: https://orcid.org/0000-0003-1354-7729)
- Hong Shen (ORCID: https://orcid.org/0000-0002-9634-8321)
- Jing Zhou (ORCID: https://orcid.org/0000-0001-7218-2462)
- Jie Wu (ORCID: https://orcid.org/0009-0001-1260-4202)
- Hanxiao Lv (ORCID: https://orcid.org/0009-0000-1677-8624)
- Shanshan Zhou (ORCID: https://orcid.org/0000-0002-2984-6435)
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Phytochemical Analysis
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1002/pca.70021
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.38