Gut microbiota and metabolite signatures predict severe immune-related adverse events in advanced hepatobiliary cancers
Patients with severe irAEs exhibited unique changes in microbiota-fungi-metabolite interactions. Gut microbiota- and/or metabolite-based algorithms could be used as additional tools for predicting severe irAEs and as potential prognostic markers in advanced hepatobiliary cancers.
Authors
- Jiashuo Chao (ORCID: https://orcid.org/0000-0002-6578-5967)
- Hanping Wang (ORCID: https://orcid.org/0000-0003-3540-2280)
- Chengpei Zhu (ORCID: https://orcid.org/0000-0002-0291-782X)
- Yajun Liang
- Jingnan Xue
- Xinting Sang (ORCID: https://orcid.org/0000-0003-1952-0527)
- Ziyu Xun
- Shanshan Wang (ORCID: https://orcid.org/0000-0001-9763-9019)
- Ning Cong (ORCID: https://orcid.org/0000-0001-7163-3698)
- Taifeng Zhu
- Haitao Zhao (ORCID: https://orcid.org/0000-0002-3444-8044)
- Chenchen Zhang (ORCID: https://orcid.org/0000-0001-8563-5002)
- Li Zhang (ORCID: https://orcid.org/0000-0002-3617-2627)
- Wenbin Xue (ORCID: https://orcid.org/0000-0003-1876-8539)
- Zhou Lan
- Zilun Pu
- Dongya Zhang (ORCID: https://orcid.org/0000-0002-9036-4590)
- Yunchao Wang (ORCID: https://orcid.org/0000-0002-3702-3826)
- Xiaobo Yang (ORCID: https://orcid.org/0000-0001-6164-4131)
- Xianzhi Jiang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Guangzhou Education Bureau (CN)
- Guangzhou Experimental Station (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1016/j.jare.2025.08.016
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Society of Clinical Oncology