MiR-7 inhibits progression of glioblastoma by impairing autophagy resolution, energy metabolism and ECM remodeling
Altogether, our study provides solid, convincing evidence demonstrating that miR-7 might be used as a promising therapeutic target for GBM, paving the way to explore its potential as novel biomarker and actionable target candidate for this lethal cancer.
Authors
- Raul Miguel Luque (ORCID: https://orcid.org/0000-0002-7585-1913)
- Mario Fernández-de Frutos
- Manuel David Gahete (ORCID: https://orcid.org/0000-0002-4578-2179)
- Marta Torrecilla-Parra (ORCID: https://orcid.org/0000-0002-5950-9181)
- Antonio C. Fuentes-Fayos (ORCID: https://orcid.org/0000-0003-2069-4823)
- Virginia Pardo (ORCID: https://orcid.org/0000-0001-9787-8722)
- Rebeca Busto (ORCID: https://orcid.org/0000-0001-9869-4087)
- Ana Pérez-García
- Miguel E. G-García (ORCID: https://orcid.org/0000-0001-6941-6715)
- José Luis López-Aceituno (ORCID: https://orcid.org/0000-0003-2808-1175)
- Carmen Zamora (ORCID: https://orcid.org/0000-0003-3616-6734)
- Juan Aranda (ORCID: https://orcid.org/0000-0002-5598-2465)
- Cristina M. Ramírez (ORCID: https://orcid.org/0000-0003-2589-0786)
- Cristina Puigdueta
Institutions
- Madrid Institute for Advanced Studies (ES)
- Universidad Complutense de Madrid (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- IMDEA Food (ES)
- Hospital Universitario Ramón y Cajal (ES)
- University of Córdoba (ES)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s13046-025-03504-6
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Fundación SEEN
- Ministerio de Ciencia, Innovación y Universidades
- European Commission
- Ministerio de Sanidad, Servicios Sociales e Igualdad
- Consejería de Educación, Juventud y Deporte, Comunidad de Madrid
- Consejería de Educación e Investigación
- Junta de Andalucía
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación
- European Social Fund