Levodopa‐Carbidopa Intestinal Gel Improves Dyskinesia in Parkinson's Disease: Post Hoc Analysis from the <scp>COSMOS</scp> Study
LCIG led to reductions in dyskinesia severity, regardless of baseline dyskinesia burden. Dyskinesia duration improved in patients with high dyskinesia burden but not in those with low dyskinesia burden.
Authors
- Cleanthe Spanaki (ORCID: https://orcid.org/0000-0001-9824-6620)
- Tanya Gurevich (ORCID: https://orcid.org/0000-0003-2092-9848)
- Mihaela Simu (ORCID: https://orcid.org/0000-0001-9676-1282)
- Per Svenningsson (ORCID: https://orcid.org/0000-0001-6727-3802)
- Abdallah Saad (ORCID: https://orcid.org/0000-0003-2968-463X)
- Lars Bergmann (ORCID: https://orcid.org/0000-0002-8603-8549)
- Robert Jech (ORCID: https://orcid.org/0000-0002-9732-8947)
- Alfonso A. Fasano (ORCID: https://orcid.org/0000-0001-5346-0180)
- Lydia Vela (ORCID: https://orcid.org/0000-0001-6663-395X)
- Juan Carlos Parra (ORCID: https://orcid.org/0000-0002-5613-6121)
- Norbert Kovács (ORCID: https://orcid.org/0000-0002-7332-9240)
- József Attila Szász (ORCID: https://orcid.org/0000-0003-1675-036X)
Institutions
- Tel Aviv University (IL)
- Charles University (CZ)
- Toronto Western Hospital (CA)
- Tel Aviv Sourasky Medical Center (IL)
- Karolinska Institutet (SE)
- AbbVie (United States) (US)
- Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș (RO)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
- Hospital Universitario Fundación Alcorcón (ES)
- Krembil Foundation (CA)
- University Hospital of Heraklion (GR)
- General University Hospital in Prague (CZ)
- Krembil Research Institute
- University of Pecs (HU)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1002/mdc3.70222
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- GlaxoSmithKline
- Sanofi
- Teva Pharmaceutical Industries
- Boston Scientific Corporation
- European Commission
- Kommunfullmäktige, Stockholms Stad
- University of Toronto
- Knut och Alice Wallenbergs Stiftelse
- EVER Neuro Pharma
- Servier
- H. Lundbeck A/S
- Ipsen
- AOP Orphan
- Allergan