SCAN-ACT: adoptive T cell therapy target discovery through single-cell transcriptomics
This work provides a robust data repository along with a web-based and user-friendly set of analysis tools to accelerate ACT development for solid tumors ( https://scanact.stanford.edu/ ).
Authors
- Nam Q. Bui (ORCID: https://orcid.org/0000-0001-6896-4349)
- Danielle Graham (ORCID: https://orcid.org/0000-0003-2922-6268)
- Kristen N. Ganjoo (ORCID: https://orcid.org/0000-0003-0452-9967)
- Matt van de Rijn (ORCID: https://orcid.org/0000-0002-1909-9739)
- Everett J. Moding (ORCID: https://orcid.org/0000-0001-7913-5351)
- Minggui Pan (ORCID: https://orcid.org/0000-0002-8368-6524)
- Paul H. Huang (ORCID: https://orcid.org/0000-0003-3972-5087)
- Aastha Pal (ORCID: https://orcid.org/0000-0002-4555-589X)
- Wei Jiang (ORCID: https://orcid.org/0000-0003-1591-4721)
- Ajay Subramanian (ORCID: https://orcid.org/0000-0001-7892-886X)
- Stefano Testa (ORCID: https://orcid.org/0000-0001-5632-5021)
- Jack Pengfei Tang (ORCID: https://orcid.org/0000-0003-4479-9638)
- Sarah Dry (ORCID: https://orcid.org/0000-0002-1858-5225)
- Sushama Varma (ORCID: https://orcid.org/0000-0001-8137-0641)
- Anusha Kalbasi (ORCID: https://orcid.org/0000-0001-8692-1457)
- Sara Arfan
Institutions
- Cedars-Sinai Medical Center (US)
- Boston Children's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Institute of Cancer Research (GB)
- University of California, Los Angeles (US)
- Jingdong (China) (CN)
- Stanford University (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s13073-025-01514-9
- Citations
- 3
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Cancer Research Institute
- National Institutes of Health