The role of skin testing, drug challenge and IFN-γ ELISpot in delayed hypersensitivity to iodinated contrast media
dIDT allowed confirmation of T cell-mediated allergy to the implicated ICM in 85% of patients with a strong clinical suspicion of DHR and identification of non-cross-reactive ICM in 35% of patients. The IFN-y ELISpot was not useful in the four patients tested.
Authors
- Moneerah AlGassim (ORCID: https://orcid.org/0000-0002-6612-6963)
- Jean-Francois Toupin
- Jason A. Trubiano (ORCID: https://orcid.org/0000-0002-5111-6367)
- Effie Mouhtouris (ORCID: https://orcid.org/0000-0003-3491-2633)
- Christos Tsoukas (ORCID: https://orcid.org/0009-0008-0628-9542)
- Ghislaine Annie Clarisse Isabwe (ORCID: https://orcid.org/0000-0002-5557-2415)
- Moshe Ben‐Shoshan (ORCID: https://orcid.org/0000-0001-9083-1518)
- Natasha E. Holmes (ORCID: https://orcid.org/0000-0001-8501-4054)
- Ana Maria Copaescu (ORCID: https://orcid.org/0000-0002-9183-5032)
- Kyra Chua (ORCID: https://orcid.org/0000-0001-8826-7137)
- Florian Stehlin (ORCID: https://orcid.org/0000-0003-1687-7811)
- Derek Lee (ORCID: https://orcid.org/0000-0002-6028-8929)
- Elizabeth J Phillips
- Ibtihal Al Otaibi
Institutions
- The University of Melbourne (AU)
- Murdoch University (AU)
- Montreal General Hospital (CA)
- Peter MacCallum Cancer Centre (AU)
- McGill University Health Centre (CA)
- Centre Hospitalier Universitaire Vaudois (CH)
- Peter Doherty Institute (AU)
- Ministry of Health (SA)
- Austin Health (AU)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Allergy Asthma and Clinical Immunology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s13223-025-00982-3
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- McGill University
- Austin Medical Research Foundation
- McGill University Health Centre
- Centre Hospitalier Universitaire Vaudois
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council