Merlin immunohistochemistry is a reliable surrogate marker for <i>NF2</i> gene alterations in meningioma
These findings suggest that Merlin immunohistochemistry could serve as a reliable and practical surrogate marker for NF2 alterations in meningioma. It may support molecular-based classification and risk stratification in clinical and research settings. However, caution is warranted in cases with cautery tissue damage and prominent macrophages, which can obscure staining patterns.
Authors
- Satoru Miyawaki (ORCID: https://orcid.org/0000-0001-6369-3391)
- Tetsuo Ushiku (ORCID: https://orcid.org/0000-0002-1763-8380)
- Atsushi Okano (ORCID: https://orcid.org/0000-0001-7016-4965)
- Nobuhito Saito (ORCID: https://orcid.org/0000-0001-9756-781X)
- Masako Ikemura (ORCID: https://orcid.org/0000-0002-7148-778X)
- Mayu Kashiwagi‐Hakozaki (ORCID: https://orcid.org/0000-0003-4902-898X)
- Yu Teranishi (ORCID: https://orcid.org/0000-0001-7448-742X)
Institutions
- University of Tokyo Hospital (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Histopathology
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1111/his.15539
- Citations
- 2
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 2.78