CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis

Our findings demonstrate that CREB and Kras∗ promote irreversible acinar-to-ductal metaplasia, accelerating pancreatic cancer progression with ACP. Targeting CREB may present a promising strategy to mitigate inflammation-driven pancreatic tumorigenesis.

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Publication Details

Journal
Cellular and Molecular Gastroenterology and Hepatology
Published
2025-01-01
DOI
https://doi.org/10.1016/j.jcmgh.2025.101606
Citations
6
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
Field-Weighted Citation Impact
6.27

Funders

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article

CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis

Austin R. Dosch, Tulasigeri M. Totiger, Nipun B. Merchant, Varunkumar Krishnamoorthy et al.
6 citations
Cellular and Molecular Gastroenterology and Hepatology
Pancreatic and Hepatic Oncology Research
6.27
article

CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis

Austin R. Dosch, Tulasigeri M. Totiger, Nipun B. Merchant, Varunkumar Krishnamoorthy, Nagaraj S. Nagathihalli, Michael N. VanSaun, Sudhakar Jinka, Vanessa T. Garrido, Edmond W. Box, Siddharth Mehra, Samara P. Singh, Zhiqun Zhou, Anna Maria Bianchi, Supriya Srinivasan, Iago De Castro Silva, Yuguang Ban, Haleh Amirian, Manan Patel, Jashodeep Datta
article en
6 citations

Abstract

Our findings demonstrate that CREB and Kras∗ promote irreversible acinar-to-ductal metaplasia, accelerating pancreatic cancer progression with ACP. Targeting CREB may present a promising strategy to mitigate inflammation-driven pancreatic tumorigenesis.

Cellular and Molecular Gastroenterology and HepatologyVol. 19(12)
University of Miami (US), The University of Kansas Cancer Center (US), University of Miami Health System (US), University of Kansas Medical Center (US), Sylvester Comprehensive Cancer Center (US)
Florida Department of Health, National Cancer Institute
Good health and well-being
Openalex Percentile: Top 3%
Pancreatic and Hepatic Oncology Research
6.27
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