CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis
Our findings demonstrate that CREB and Kras∗ promote irreversible acinar-to-ductal metaplasia, accelerating pancreatic cancer progression with ACP. Targeting CREB may present a promising strategy to mitigate inflammation-driven pancreatic tumorigenesis.
Authors
- Austin R. Dosch (ORCID: https://orcid.org/0000-0001-9071-1591)
- Tulasigeri M. Totiger (ORCID: https://orcid.org/0000-0002-4262-4458)
- Nipun B. Merchant (ORCID: https://orcid.org/0000-0002-3399-9776)
- Varunkumar Krishnamoorthy (ORCID: https://orcid.org/0000-0002-1621-8472)
- Nagaraj S. Nagathihalli (ORCID: https://orcid.org/0000-0003-2373-3293)
- Michael N. VanSaun (ORCID: https://orcid.org/0000-0002-2538-8107)
- Sudhakar Jinka (ORCID: https://orcid.org/0000-0001-5070-0046)
- Vanessa T. Garrido (ORCID: https://orcid.org/0000-0002-5014-1608)
- Edmond W. Box
- Siddharth Mehra (ORCID: https://orcid.org/0000-0003-1639-8087)
- Samara P. Singh (ORCID: https://orcid.org/0000-0002-5911-1499)
- Zhiqun Zhou (ORCID: https://orcid.org/0000-0001-5248-8931)
- Anna Maria Bianchi (ORCID: https://orcid.org/0000-0002-8290-7460)
- Supriya Srinivasan
- Iago De Castro Silva (ORCID: https://orcid.org/0000-0002-3898-6173)
- Yuguang Ban (ORCID: https://orcid.org/0000-0002-2874-0647)
- Haleh Amirian (ORCID: https://orcid.org/0000-0002-6094-1342)
- Manan Patel (ORCID: https://orcid.org/0000-0001-6978-960X)
- Jashodeep Datta
Institutions
- University of Miami (US)
- The University of Kansas Cancer Center (US)
- University of Miami Health System (US)
- University of Kansas Medical Center (US)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101606
- Citations
- 6
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Florida Department of Health
- National Cancer Institute