Initiation and Dose of Methadone Monotherapy vs Combination Therapy, 2015 to 2023
In this repeated cross-sectional study of methadone initiations, a shift toward higher starting doses and in combination with slow-release oral morphine was noted. Provision of subsequent rapid dose titration remained limited, representing a potential missed opportunity for quicker attainment of therapeutic doses.
Authors
- Nikki Bozinoff (ORCID: https://orcid.org/0000-0001-9512-7407)
- Tara Gomes (ORCID: https://orcid.org/0000-0002-1468-1965)
- Tony Antoniou (ORCID: https://orcid.org/0000-0002-6984-8953)
- Ria Garg (ORCID: https://orcid.org/0000-0003-2572-0170)
- Jennifer Wyman
- Beth Sproule (ORCID: https://orcid.org/0000-0001-7960-3696)
- Charlotte Munro (ORCID: https://orcid.org/0000-0003-1911-7586)
- Jin Luo (ORCID: https://orcid.org/0000-0002-9462-2016)
Institutions
- St. Michael's Hospital (CA)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Women's College Hospital (CA)
- Ontario Drug Policy Research Network (CA)
- Institute for Clinical Evaluative Sciences (CA)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.27290
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ontario College of Pharmacists
- Canadian Institutes of Health Research