Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Sp
Changes in blood lipid profiles in type 2 diabetes, particularly when complicated by metabolic dysfunction-associated steatotic liver disease (MASLD), have not been fully elucidated. Does MASLD influence the plasma lipidome in patients with type 2 diabetes? Patients with MASLD exhibited elevated levels of myristic acid (FA 14:0) in plasma triglycerides, which significantly decreased after comprehensive diabetes treatment. Elevated FA 14:0 levels in triglycerides may be associated with MASLD pathogenesis in type 2 diabetes.
Authors
- Ayako Hidaka
- Motonao Nakao (ORCID: https://orcid.org/0000-0003-0927-7762)
- Shigero Hosoe
- Naoto Katakami (ORCID: https://orcid.org/0000-0001-9020-8320)
- Masatomo Takahashi (ORCID: https://orcid.org/0000-0002-2493-2684)
- Iichiro Shimomura (ORCID: https://orcid.org/0000-0002-0851-9603)
- Yutaka Konya (ORCID: https://orcid.org/0000-0002-3885-9959)
- Sachiko Obara
- Mitsuyoshi Takahara (ORCID: https://orcid.org/0000-0001-5105-041X)
- Takeshi Bamba (ORCID: https://orcid.org/0000-0002-7442-2738)
- Yoshihiro Izumi (ORCID: https://orcid.org/0000-0003-4608-4652)
- Kazuo Omori
- Naohiro Taya
Institutions
- Kyushu University (JP)
- Osaka City University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Diabetes
- Published
- 2025-08-14
- DOI
- https://doi.org/10.2337/db25-0099
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Manpei Suzuki Diabetes Foundation
- Japan Diabetes Foundation
- Core Research for Evolutional Science and Technology