Novel Molecular Signatures of Peripheral Regulatory T Cells in Kidney Disease Associated with Type 1 Diabetes
Importantly, our analyses identified two differentially expressed Treg ligand genes (LRRC4B, TGM2), which interacted with the receptors on kidney cells (PTPRD/F/S, ADGRG1) in silico, providing potential mechanistic insights into the role of Tregs in DKD progression. Together, our work supports the yet unappreciated role of Tregs in DKD and opens new research avenues to further consolidate their causal relationship.
Authors
- Alexia Peña (ORCID: https://orcid.org/0000-0002-6834-4876)
- Giles Best (ORCID: https://orcid.org/0000-0003-2685-3880)
- Elif Ilhan Ekinci (ORCID: https://orcid.org/0000-0003-2372-395X)
- Wilson K. M. Wong (ORCID: https://orcid.org/0000-0001-7736-6834)
- Cheng Xue Qin (ORCID: https://orcid.org/0000-0003-2169-2686)
- Sarah J. Glastras (ORCID: https://orcid.org/0000-0002-9317-1348)
- Soon Wei Wong
- Sih Min Tan (ORCID: https://orcid.org/0000-0003-4195-0523)
- Devy Deliyanti (ORCID: https://orcid.org/0000-0002-0390-3454)
- Steven James (ORCID: https://orcid.org/0000-0002-3928-9206)
- Mugdha V. Joglekar (ORCID: https://orcid.org/0000-0001-5346-2266)
- Darling Rojas-Canales
- Amita Bansal (ORCID: https://orcid.org/0000-0001-8716-9922)
Institutions
- Australian National University (AU)
- Camden and Campbelltown Hospitals (AU)
- The University of Sydney (AU)
- Translational Research Institute (AU)
- The University of Melbourne (AU)
- Flinders University (AU)
- University of the Sunshine Coast (AU)
- Discovery Institute (US)
- Royal North Shore Hospital (AU)
- Monash Medical Centre (AU)
- Flinders Medical Centre (AU)
- Austin Health (AU)
- Monash University (AU)
- The University of Adelaide (AU)
- Western Sydney University (AU)
Publication Details
- Journal
- Kidney360
- Published
- 2025-08-14
- DOI
- https://doi.org/10.34067/kid.0000000921
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00