The Mechanism of Calcium Handling Proteins and NF-κB in Calcium Dyshomeostasis of Cardiomyocytes Caused by Acute MDMA Exposure.
MDMA can lead to an increase of calcium ion concentration in cardiomyocytes. Calcium ions are involved in myocardial toxicity of MDMA. The mechanism is related to changes in calcium handling proteins, mainly associated with the increased expression of RyR2. MDMA can up-regulate the intracellular activity of NF-κB through the PKCζ-NF-κB pathway and affect calcium handling proteins, which aggravate intracellular calcium overload during acute MDMA exposure.
Authors
- Xinghuan Wang (ORCID: https://orcid.org/0000-0003-3497-0024)
- Rongshuai Wang
- Yanfei Deng (ORCID: https://orcid.org/0000-0002-7367-2233)
- Sizhe Huang (ORCID: https://orcid.org/0009-0003-8923-8946)
- Zijiao Ding (ORCID: https://orcid.org/0009-0004-1948-7135)
- Liang Ren (ORCID: https://orcid.org/0000-0002-5784-367X)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-5348-7671)
- Yong Liu (ORCID: https://orcid.org/0000-0001-8315-9751)
- Liang Liu (ORCID: https://orcid.org/0000-0002-8437-5998)
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-25
- DOI
- https://doi.org/10.12116/j.issn.1004-5619.2024.440503
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00