The multi-target intervention reveals the mechanism by which Finerenone alleviates Polymyxin B-induced kidney injury: an integrated study of network pharmacology, transcriptomics, and molecular docking
This study provides the first evidence elucidating the central role of the STAT3-CASP3-HIF1A axis in PMB-induced nephrotoxicity and demonstrates that Finerenone exerts multi-targeted protective effects primarily through direct interactions with STAT3, CASP3, and HIF1A. These findings highlight the significant therapeutic potential of Finerenone for treating acute drug-induced kidney injury, extending its application beyond chronic kidney diseases. Future research should validate its efficacy in vivo and systematically explore synergistic effects with other therapeutic strategies to facilitate clinical translation.
Authors
- Yongchuan Chen (ORCID: https://orcid.org/0000-0003-0274-5797)
- Pu Yao
- Shenglan Shang (ORCID: https://orcid.org/0000-0002-2771-6100)
- Wěi Li (ORCID: https://orcid.org/0000-0002-9522-4474)
- H. J. Yang (ORCID: https://orcid.org/0009-0004-8274-9863)
- Hong Zhang (ORCID: https://orcid.org/0000-0003-3945-6323)
- Ge Yang (ORCID: https://orcid.org/0000-0002-5007-4425)
Institutions
- Army Medical University (CN)
- Wuhan University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Southwest Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
- Central Hospital of Wuhan (CN)
- Chongqing Cancer Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.ejphar.2025.177968
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00