Palladium-Catalyzed α-Arylation of Nitroalkanes with Aryl Fluorosulfonates for Convenient Access to α-Arylated Nitroalkanes
Palladium-catalyzed α-arylation of nitroalkanes by utilizing aryl fluorosulfonates as effective arylating agents can be realized. The reactions proceed effectively through C-O bond activation to produce a variety of valuable α-arylated nitroalkanes in modest to good yields with wide functional group compatibility. Additionally, late-stage functionalization of complex molecules and scale-up synthesis can be achieved.
Authors
- Chenlong Zhu (ORCID: https://orcid.org/0000-0003-4564-3117)
- Fei Zhao (ORCID: https://orcid.org/0000-0003-1841-4466)
- Weidong Rao (ORCID: https://orcid.org/0000-0002-6088-7278)
- Xue‐Qiang Chu (ORCID: https://orcid.org/0000-0002-9173-1508)
- Zhi‐Liang Shen (ORCID: https://orcid.org/0000-0002-3365-9288)
- Hao Xu (ORCID: https://orcid.org/0000-0002-6069-3246)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0002-7629-4178)
- Chengping Miao
Institutions
- Nanjing Tech University (CN)
- Nanjing Forestry University (CN)
- Jiaxing University (CN)
- Institute of Chemical Industry of Forest Products (CN)
- Fluorochem (United States) (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1021/acs.joc.5c01502
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanjing Tech University