HuR-Regulated Extracellular Vesicles Promote Endothelial Cell Remodeling in Pancreatic Cancer
Targeting the abnormal pancreatic cancer vasculature remains a significant barrier to immunosurveillance and drug delivery. This study demonstrated that the tumor-intrinsic protein HuR regulates pancreatic cancer EVs, which, in turn, alters endothelial cell behavior. These findings reveal a novel mechanism by which tumor-intrinsic factors shape the vascular microenvironment and suggest that altering EV content could modulate endothelial cell function.
Authors
- Valerie Calvert (ORCID: https://orcid.org/0000-0002-5075-7728)
- Matthew Reyer (ORCID: https://orcid.org/0000-0002-9195-5720)
- Margaret Haerr (ORCID: https://orcid.org/0000-0002-7917-9722)
- Yifei Guo (ORCID: https://orcid.org/0000-0002-1744-0227)
- Katelyn T. Byrne (ORCID: https://orcid.org/0000-0002-2459-9041)
- Alexandra Q. Bartlett (ORCID: https://orcid.org/0000-0001-7912-6084)
- Jennifer M. Finan (ORCID: https://orcid.org/0000-0001-7706-1643)
- Kevin MacPherson‐Hawthorne (ORCID: https://orcid.org/0000-0002-2657-8762)
- Canping Chen (ORCID: https://orcid.org/0000-0003-4021-8592)
- Zheng Xia (ORCID: https://orcid.org/0000-0003-3364-8324)
- Jonathan R. Brody (ORCID: https://orcid.org/0000-0003-3680-3270)
- Rosalie C. Sears (ORCID: https://orcid.org/0000-0003-1558-2413)
- Hen Halamish
- Emanuel F. Petricoin (ORCID: https://orcid.org/0000-0001-8787-5990)
- Olayinka Lamikanra
Institutions
- George Mason University (US)
- Oregon Health & Science University (US)
- Oregon Health and Science University Hospital (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0355
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- American Association for Cancer Research
- Pancreatic Cancer Action Network
- Hirshberg Foundation for Pancreatic Cancer Research
- Oregon Health and Science University
- National Institutes of Health
- Knight Cancer Institute, Oregon Health and Science University
- National Cancer Institute