Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study
Several metabolites were found to mediate the association between PRS and incident T2DM. These findings may contribute to a better understanding of the metabolic pathways involved in genetic susceptibility to T2DM.
Authors
- Taku Obara (ORCID: https://orcid.org/0000-0002-3674-1674)
- Kazuki Kumada (ORCID: https://orcid.org/0000-0002-2970-7742)
- Nobuo Fuse (ORCID: https://orcid.org/0000-0003-0237-4746)
- Tomoko Kobayashi (ORCID: https://orcid.org/0000-0002-2226-6702)
- Satoshi Nagaie (ORCID: https://orcid.org/0000-0002-8152-4556)
- Sayuri Tokioka (ORCID: https://orcid.org/0000-0003-0751-1674)
- Rieko Hatanaka (ORCID: https://orcid.org/0000-0001-5729-4837)
- Junichi Sugawara (ORCID: https://orcid.org/0000-0001-8026-2550)
- Akira Narita (ORCID: https://orcid.org/0000-0002-9076-0710)
- Eiichi N. Kodama (ORCID: https://orcid.org/0000-0002-6622-2752)
- Kengo Kinoshita (ORCID: https://orcid.org/0000-0003-3453-2171)
- Takumi Hirata (ORCID: https://orcid.org/0000-0003-2899-6762)
- Kinuko Ohneda (ORCID: https://orcid.org/0000-0002-6919-6529)
- Masato Takase (ORCID: https://orcid.org/0000-0001-7009-387X)
- Yohei Hamanaka (ORCID: https://orcid.org/0000-0003-4169-7767)
- S. Koshiba (ORCID: https://orcid.org/0000-0003-2001-1949)
- Kotaro Nochioka (ORCID: https://orcid.org/0000-0001-8297-8624)
- Naoki Nakaya (ORCID: https://orcid.org/0000-0002-5344-8170)
- Soichi Ogishima (ORCID: https://orcid.org/0000-0001-8613-2562)
- Ippei Takahashi (ORCID: https://orcid.org/0000-0003-4858-2209)
- Mana Kogure (ORCID: https://orcid.org/0000-0003-2585-2405)
- Hisashi Ohseto (ORCID: https://orcid.org/0000-0001-6716-9095)
- Koichi Matsuda
- Kumi Nakaya (ORCID: https://orcid.org/0000-0003-0027-6667)
- Ippei Chiba (ORCID: https://orcid.org/0000-0003-1966-3595)
- Mami Ishikuro (ORCID: https://orcid.org/0000-0002-2884-0023)
- Masatsugu Orui (ORCID: https://orcid.org/0000-0002-4871-8455)
- Eiji Hishinuma (ORCID: https://orcid.org/0000-0001-8644-5120)
- Shinichi Kuriyama (ORCID: https://orcid.org/0000-0002-6445-0911)
- Ikuko N. Motoike (ORCID: https://orcid.org/0000-0002-5528-7964)
- Tomohiro Nakamura (ORCID: https://orcid.org/0000-0002-8349-2367)
- Yoko Izumi (ORCID: https://orcid.org/0000-0001-8946-0625)
- Masayuki Yamamoto (ORCID: https://orcid.org/0000-0002-9073-9436)
- Naho Tsuchiya
- Atsushi Hozawa
Institutions
- Suzuki (Japan) (JP)
- Tohoku University (JP)
- Kyoto Women's University (JP)
- Tohoku University Hospital (JP)
- Tohoku Medical Megabank Organization (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s12933-025-02849-8
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science