Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study

Several metabolites were found to mediate the association between PRS and incident T2DM. These findings may contribute to a better understanding of the metabolic pathways involved in genetic susceptibility to T2DM.

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Publication Details

Journal
Cardiovascular Diabetology
Published
2025-08-14
DOI
https://doi.org/10.1186/s12933-025-02849-8
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
article
Field-Weighted Citation Impact
0.00

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Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study

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Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study

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article en

Abstract

Several metabolites were found to mediate the association between PRS and incident T2DM. These findings may contribute to a better understanding of the metabolic pathways involved in genetic susceptibility to T2DM.

Cardiovascular DiabetologyVol. 24(1)
Suzuki (Japan) (JP), Tohoku University (JP), Kyoto Women's University (JP), Tohoku University Hospital (JP), Tohoku Medical Megabank Organization (JP), Tokyo Metropolitan Institute of Gerontology (JP), The University of Tokyo (JP)
Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science
Openalex Percentile: Top 82%
Metabolomics and Mass Spectrometry Studies
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