HAS1high cancer associated fibroblasts located at the tumor invasion front zone promote oral squamous cell carcinoma invasion via ECM remodeling
CAF<sup>IF</sup> with plump cell morphology showed pro-invasive abilities, driven in part by HAS1 overexpression and ECM remodeling, suggesting that targeting HAS1-driven ECM remodeling could be a promising therapeutic strategy.
Authors
- Wanqiu Lu
- X. Y. Wang (ORCID: https://orcid.org/0000-0003-2273-3371)
- Liang Ding (ORCID: https://orcid.org/0000-0002-1043-0923)
- Qiuya Yu (ORCID: https://orcid.org/0000-0002-6073-0916)
- Wanyong Jin
- Liyuan Yu (ORCID: https://orcid.org/0000-0002-3341-9225)
- Qingang Hu (ORCID: https://orcid.org/0000-0001-8325-9488)
- Ting Zhou (ORCID: https://orcid.org/0000-0002-0405-0115)
- Yanhong Ni
- Xiaoxin Zhang
Institutions
- China Pharmaceutical University (CN)
- Stomatology Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s13046-025-03493-6
- Citations
- 4
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- Nanjing University
- Nanjing Medical Science and Technique Development Foundation
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China