High Schistosoma mansoni infection intensity is associated with distinct gut microbiota and low levels of systemic cytokines in children along the Albert-Nile, Northern Uganda
There are alterations in the gut microbiota of S. mansoni infected children with distinct genera that discriminate the high and low infection intensity that could be potentially used as biomarkers. There is an association between the gut microbiota and systemic cytokine response whose mechanism in chronic disease pathophysiology needs to be further investigated.
Authors
- Rhona Baingana (ORCID: https://orcid.org/0000-0002-9954-8257)
- Harry Noyes (ORCID: https://orcid.org/0000-0002-0656-200X)
- Isaac Ssewanyana
- Magambo Phillip Kimuda (ORCID: https://orcid.org/0000-0003-3911-8359)
- Gloria Cuu
- Annette MacLeod (ORCID: https://orcid.org/0000-0002-0150-5049)
- Julius Mulindwa
- Joyce Namulondo (ORCID: https://orcid.org/0000-0002-9427-9334)
- Barbara Nerima (ORCID: https://orcid.org/0000-0002-6133-0674)
- Ibra Lujumba (ORCID: https://orcid.org/0000-0001-9937-1255)
- Oscar A. Nyangiri (ORCID: https://orcid.org/0000-0003-2741-2921)
- Stephen Tukwasibwe (ORCID: https://orcid.org/0000-0002-6469-6516)
- Enock Matovu
- Aloysious Ssemaganda
- Caroline Musiime
- Caroline Mwubaha
Institutions
- University of Liverpool (GB)
- Wellcome Centre for Molecular Parasitology (GB)
- Infectious Diseases Research Collaboration (UG)
- National Public Health Laboratory (NP)
- Makerere University (UG)
- University of Glasgow (GB)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1186/s12866-025-04252-5
- Citations
- 1
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- National Institutes of Health