Aligned silk fibroin fiber conduits with enhanced capability for guiding peripheral nerve repair

This study demonstrates that aligned silk fibroin nerve conduits (ASNCs) significantly enhance peripheral nerve regeneration, achieving functional recovery comparable to autologous nerve grafts. By leveraging the directional guidance of aligned fibers, ASNCs promote axonal growth and mitigate the limitations of current treatments, such as donor site morbidity and insufficient donor tissue availability. These findings advance the field of neural tissue engineering by providing a scalable, biomaterial-based alternative for peripheral nerve repair. The potential clinical translation of ASNCs offers a promising therapeutic strategy for addressing long-gap nerve defects, with implications for improving patient outcomes and expanding treatment options.