Molecular Characterization of Patients with Metastatic Invasive Lobular Carcinoma: Using Real-World Data to Describe This Unique Clinical Entity
Our real-world data illustrate the distinct molecular landscape of CDH1-mutant metastatic ILC, and therapies targeting ERBB2 and PIK3CA should be further investigated in CDH1-mutant ILC. ILC differs from mixed and IBC-NST at a transcriptional level, suggesting the possibility of using CDH1 RNA expression levels to improve classification of ILC.
Authors
- Ian S. Hagemann (ORCID: https://orcid.org/0000-0002-3855-9745)
- Talal Ahmed (ORCID: https://orcid.org/0000-0002-5383-5349)
- Katie Navo (ORCID: https://orcid.org/0009-0005-2511-6530)
- Andrew A. Davis (ORCID: https://orcid.org/0000-0003-3663-2133)
- Massimo Cristofanilli (ORCID: https://orcid.org/0000-0002-4194-7175)
- Calvin Chao (ORCID: https://orcid.org/0000-0002-9704-9227)
- Ami N. Shah (ORCID: https://orcid.org/0000-0003-1347-3782)
- Lorenzo Gerratana (ORCID: https://orcid.org/0000-0002-8313-4834)
- Paolo D’Amico (ORCID: https://orcid.org/0000-0001-9155-425X)
- Ellen Jaeger (ORCID: https://orcid.org/0009-0005-1386-614X)
- Carolina Reduzzi (ORCID: https://orcid.org/0000-0003-0514-0152)
- Amir Behdad (ORCID: https://orcid.org/0000-0002-3944-2792)
- Kayla Viets Layng (ORCID: https://orcid.org/0000-0001-7116-334X)
- William J. Gradishar (ORCID: https://orcid.org/0000-0002-2772-3140)
- Lisa Flaum (ORCID: https://orcid.org/0009-0007-4837-0640)
- Elizabeth Mauer (ORCID: https://orcid.org/0009-0001-8033-0696)
Institutions
- Northwestern University (US)
- University of Udine (IT)
- Washington University in St. Louis (US)
- Cornell University (US)
- Tempus Labs (United States) (US)
- National Cancer Institute (UA)
- Northwestern Medicine (US)
- Weill Cornell Medicine (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0359
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94