Fully closed‐loop control with ultra‐rapid versus standard insulin lispro: A randomised crossover study simulating missed meal boluses
URIL in a fully closed-loop setting showed a clinically meaningful trend towards improved TIR and reduced hyperglycaemia compared to IL. Further advancements in faster-acting insulins are needed to alleviate the burden of pre-meal bolusing and enhance fully closed-loop performance in the future.
Authors
- Jonathan Lim (ORCID: https://orcid.org/0000-0003-3682-8910)
- Catherine Fullwood (ORCID: https://orcid.org/0000-0003-4136-2027)
- Roman Hovorka (ORCID: https://orcid.org/0000-0003-2901-461X)
- Hood Thabit (ORCID: https://orcid.org/0000-0001-6076-6997)
- Lalantha Leelarathna (ORCID: https://orcid.org/0000-0001-9602-1962)
- Malgorzata E. Willinska
Institutions
- University of Cambridge (GB)
- Manchester Academic Health Science Centre (GB)
- Manchester Royal Infirmary (GB)
- University of Manchester (GB)
- Manchester University NHS Foundation Trust (GB)
- Wellcome/MRC Institute of Metabolic Science (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Diabetic Medicine
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1111/dme.70122
- Citations
- 2
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Eli Lilly and Company
- Sanofi
- Wellcome Trust
- Insulet Corporation
- Dexcom
- Novo Nordisk
- Abbott Diabetes Care