Spatiotemporal Proliferative Heterogeneity of Intraorgan Endothelial Cells
This study uncovers regional and subtype-specific proliferation in the heart, liver, and lung, driven by distinct gene expression programs. These findings highlight the spatial and functional diversity of microvascular ECs and offer a framework for developing organ-specific vascular regenerative strategies.
Authors
- Xuekun Li (ORCID: https://orcid.org/0000-0002-6985-6363)
- Xiuzhen Huang (ORCID: https://orcid.org/0000-0002-4087-8964)
- Qiang Shu (ORCID: https://orcid.org/0000-0002-4106-6255)
- Nicola Smart (ORCID: https://orcid.org/0000-0002-3501-7254)
- Maoying Han (ORCID: https://orcid.org/0000-0003-3532-4921)
- Zhixin Kang (ORCID: https://orcid.org/0000-0003-0059-1456)
- Lei Liu (ORCID: https://orcid.org/0000-0002-5416-0099)
- Bin Zhou (ORCID: https://orcid.org/0000-0001-5278-5522)
- Zhicong Liu (ORCID: https://orcid.org/0009-0004-3082-0488)
Institutions
- Chinese University of Hong Kong (HK)
- ShanghaiTech University (CN)
- Children's Hospital of Zhejiang University (CN)
- Center for Excellence in Molecular Cell Science (CN)
- Regenerative Medicine Institute (MX)
- Institute for Advanced Study (DE)
- University of Hong Kong (HK)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1161/circresaha.125.326748
- Citations
- 2
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61