Impact of TiF <sub>4</sub> Varnish on the Oral Biofilm Microbiome in High-Caries-Risk Patients
PP, whether or not combined with fluoride varnishes, modified the biofilm microbiota. PP + TiF<sub>4</sub> varnish affected a greater number of bacterial log-ratios associated with commensal-dysbiotic balance, although no significant differences were found between treatment groups.Knowledge Transfer Statement:The findings from this study can guide clinicians in selecting the most effective fluoride varnish for high-caries-risk patients. By understanding how sodium fluoride (NaF) and titanium tetrafluoride (TiF<sub>4</sub>) varnishes modulate the oral microbiome, clinicians can develop more targeted and effective prevention strategies. This knowledge has the potential to enhance patient outcomes by optimizing caries prevention during orthodontic treatment, allowing for more personalized and microbiome-focused approaches.
Authors
- Gabriel Flores Abuna (ORCID: https://orcid.org/0000-0002-9812-4882)
- Tamara Teodoro Araújo (ORCID: https://orcid.org/0000-0002-7560-9051)
- Marília Afonso Rabelo Buzalaf (ORCID: https://orcid.org/0000-0002-5985-3951)
- Ramiro Mendonça Murata (ORCID: https://orcid.org/0000-0002-8478-6981)
- Thiago Saads Carvalho (ORCID: https://orcid.org/0000-0002-2435-1169)
- Fernanda Navas Reis (ORCID: https://orcid.org/0000-0002-8083-6064)
- Aline Dionízio (ORCID: https://orcid.org/0000-0002-8687-0124)
- Samanta Mascarenhas Moraes (ORCID: https://orcid.org/0000-0002-4256-1848)
- Vanessa Pardi (ORCID: https://orcid.org/0000-0001-7120-4332)
Institutions
- Universidade de São Paulo (BR)
- East Carolina University (US)
- Nova Southeastern University (US)
Publication Details
- Journal
- JDR Clinical & Translational Research
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1177/23800844251348180
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo